D-Ring modification of steroids: synthesis of isoxazole annulated steroids from des D-formyl alkyne via 1,3-dipolar cycloaddition reaction
نویسندگان
چکیده
The reaction of 17,17-dichloro-androst-16(E)-chloromethylene with secondary amine base afforded substitution products exocyclic D-ring ketones, in contrast to the alkaline which cleaved steroidal des-D formyl alkyne. alkyne was employed prepare annulated isoxazolo steroid via 1,3-dipolar nitrile oxide cycloaddition reaction.
منابع مشابه
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متن کامل1,3-Dipolar Cycloaddition Reaction of Dibenzalaceton with Non-stabilized Azomethinylides: Synthesis of New Spirooxindolo(pyrrolizidines/ pyrrolidines)
1,3-dipolar cycloaddition reaction of 1 mol or 2 mol of dibenzalaceton with 1 mol of non-stabilized azomethinylides generated in situ by decarboxylative condensation of isatin and proline or sarcosine give the novel new spiro-oxindolo(pyrrolizidines/ pyrrolidines) instead of bis-spirooxindolo( pyrrolizidines/ pyrrolidines).
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ژورنال
عنوان ژورنال: Synthetic Communications
سال: 2021
ISSN: ['1532-2432', '0039-7911']
DOI: https://doi.org/10.1080/00397911.2021.1955930